zengo

2022. 05. 24.

Blindspot in immune recognition

Our immune system has to recognize and destroy pathogens and tolerate nonharmful molecules of the body. T cells – sentinels of the immune system - play a key role in this process.
2022. 05. 24.

Adaptive immune recognition of cancer

Immunotherapy has revolutionized cancer treatment. However, only one-third of patients respond to the treatment. As these drugs are very expensive, it is of utmost importance to identify biomarkers that can accurately predict response.
2022. 04. 06.

HLA promiscuity

The human immune system plays a fundamental role in killing pathogens and tumors, while it is essential to tolerate healthy cells of the human body. Tumor immunotherapy has revolutionized cancer treatment in the previous two decades.
2022. 02. 03.

PhD student positions are available

We are seeking Ph.D. students to join the Systems Immunology Research Group, within the Synthetic and Systems Biology Unit of the BRC. You will study antitumor immunity and peptide immunogenicity using large datasets and modern data analysis methods.
2022. 02. 02.

Balázs Koncz has defended his PhD thesis

On 31st January, 2022, Balázs Koncz has defended his PhD thesis.
2022. 01. 28.

We have moved to the BRC

From 1st January 2022, the Systems Biology Research Group is located in the BRC, Szeged, Hungary.
2021. 09. 15.

New paper is out in PNAS

Our novel paper is published on 10th September in PNAS. See infographics and abstract in the Publication section.
2021. 09. 10.

Self-mediated positive selection of T cells sets an obstacle to the recognition of nonself

(PNAS, 2021)
2021. 09. 03.

Our newest publication is out at Nature Cancer

Check it under the Publications page or on the publishers’ site!
2021. 07. 07.

Negative trade-off between neoantigen repertoire breadth and the specificity of HLA-I molecules shapes antitumor immunity

(Nature Cancer, 2021)
2019. 01. 31.

Pathogen diversity drives the evolution of generalist MHC-II alleles in human populations

(Plos Biology, 2019)
2018. 07. 07.

Peptide presentation by HLA-DQ molecules is associated with the development of immune tolerance

(PeerJ, 2018)